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The Knighty NI
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Joined: 06 Sep 2007
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Location: Lost in space on a rather small Blue ping pong ball. :)
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 Posted: Tue May 15, 2012 4:53 pm Post subject: Fold It Game - Solve puzzles for Science |
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Has anyone had a go at this game?
If so what are your thoughts. Do we have a team there?
However, not sure if you can set up teams. There dosn't seem to be a link to a teams page or the ability to look for a team.
Seems the project is allied with or a sub project of Rosetta@Home
http://fold.it/portal/
This is their FAQ page:
http://fold.it/portal/info/faq
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The Knighty NI
Prince
Joined: 06 Sep 2007
Posts: 780
Location: Lost in space on a rather small Blue ping pong ball. :)
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| Posted: Tue May 15, 2012 7:08 pm Post subject: |
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Seems we have a team there though no one is active.
KWSN PhastPhred and Landroid are members of the team, with Furry Mark as the team manager 
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LanDroid
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Joined: 11 Jun 2002
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Location: Cincinnati, OH U.S.
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| Posted: Tue May 15, 2012 7:20 pm Post subject: |
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I've played FoldIt off and on. It's rather difficult, there is a training program that is recommended. It can get addictive after reaching a certain skill level. I'll get back into it if other Kanigits do...
I believe in general, humans manipulating proteins like in this game are still superior to random computer generations like Rosetta, but CASP10 could change that... |
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The Knighty NI
Prince
Joined: 06 Sep 2007
Posts: 780
Location: Lost in space on a rather small Blue ping pong ball. :)
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| Posted: Tue May 15, 2012 7:24 pm Post subject: |
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I'm gonna have a go and already completed half the training this evening.
Had a chat with couple of people and apparently everyone is taking part in the CASP10 competition as well via the game 
Seems interesting so going to have a go. If we can get a few Kanigts to take part this may be another avenue for the team to take part in the CASP10 competition with very few puter resources being used and can be done alongside other BONIC projects which are on the CASP projects.
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Plomos
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Joined: 26 Apr 2011
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| Posted: Wed May 16, 2012 8:41 am Post subject: |
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I downloaded it last night and started going through the training. Should be interesting to see if i can do the CASP structures 
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The Knighty NI
Prince
Joined: 06 Sep 2007
Posts: 780
Location: Lost in space on a rather small Blue ping pong ball. :)
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| Posted: Fri May 18, 2012 4:03 am Post subject: |
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Finished the training puzzles now and started with some simple ones. Seem to be doing OK.
Saw that you are only a couple of places away from me on the same puzzle Plomos
Maybe see you online over the weekend
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LanDroid
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| Posted: Fri May 18, 2012 7:15 pm Post subject: |
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| The Knighty NI wrote: | I'm gonna have a go and already completed half the training this evening. Had a chat with couple of people and apparently everyone is taking part in the CASP10 competition as well via the game
Seems interesting so going to have a go. If we can get a few Kanigts to take part this may be another avenue for the team to take part in the CASP10 competition with very few puter resources being used and can be done alongside other BONIC projects which are on the CASP projects. |
Excellent points. FoldIt is much more than a game. In addition to the CASP10 angle where humans are "competing" against computers in resolving protein folding, here is a breakthrough in AIDS research that was announced last year. A solution that had eluded professional researchers for 12 years was obtained in 10 days by FoldIt "gamers"!
| Quote: | Gamers crack HIV molecular puzzle
Video-game players have solved a molecular puzzle that stumped scientists for years, and those scientists say the accomplishment could point the way to crowdsourced cures for AIDS and other diseases.
"This is one small piece of the puzzle in being able to help with AIDS," Firas Khatib, a biochemist at the University of Washington, told me. Khatib is the lead author of a research paper on the project, published today by Nature Structural & Molecular Biology.
...The problem is that enzymes are far tougher to crack than your typical lock. There are millions of ways that the bonds between the atoms in the enzyme's molecules could twist and turn. To design the right chemical key, you have to figure out the most efficient, lowest-energy configuration for the molecule — the one that Mother Nature herself came up with.
That's where Foldit plays a role. The game is designed so that players can manipulate virtual molecular structures that look like multicolored, curled-up Tinkertoy sets. The virtual molecules follow the same chemical rules that are obeyed by real molecules. When someone playing the game comes up with a more elegant structure that reflects a lower energy state for the molecule, his or her score goes up. If the structure requires more energy to maintain, or if it doesn't reflect real-life chemistry, then the score is lower.
...The monkey-virus puzzle was one of several unsolved molecular mysteries that a colleague of Khatib's at the university, Frank DiMaio, recently tried to solve using a method that took advantage of a protein-folding computer program called Rosetta. "This was one of the cases where his method wasn't able to solve it," Khatib said.
Fortunately, the challenge fit the current capabilities of the Foldit game, so Khatib and his colleagues put the puzzle out there for Foldit's teams to work on. "This was really kind of a last-ditch effort," he recalled. "Can the Foldit players really solve it?" They could. "They actually did it in less than 10 days," Khatib said.
9/18/2011
http://cosmiclog.msnbc.msn.com/_news/2011/09/18/7802623-gamers-solve-molecular-puzzle-that-baffled-scientists
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After seeing that, I'm gonna give FoldIt another go... It has been so long, I will prolly have to re-take the training. I humbly suggest all Knights of the CASP10 / Protein Folding / medical science persuasion check this out... |
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LanDroid
Prince
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Location: Cincinnati, OH U.S.
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| Posted: Fri May 18, 2012 8:38 pm Post subject: |
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OK I played around with 556: CASP10 Target T0660. Could only get up to 8048 points and 254 place so far. 26th place for KWSN, need some help...  |
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The Knighty NI
Prince
Joined: 06 Sep 2007
Posts: 780
Location: Lost in space on a rather small Blue ping pong ball. :)
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| Posted: Sat May 19, 2012 1:32 am Post subject: |
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I'll take a look today.
Still trying to solve the first beginners puzzle for anthrax
Got up to 8970 and 316th place so far.
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LanDroid
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| Posted: Wed May 23, 2012 10:42 pm Post subject: |
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Got up to 158th place, 9525 points, 15th place for KWSN on 560: Quick CASP10 T0660.
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