KWSN Orbiting Fortress Forum Index KWSN Orbiting Fortress
KWSN Distributed Computing Teams forum
 
 FAQFAQ   SearchSearch   MemberlistMemberlist   UsergroupsUsergroups   RegisterRegister 
 ProfileProfile   Log in to check your private messagesLog in to check your private messages   Log inLog in 

New WCG project launched - Mapping Cancer Markers

 
Post new topic   Reply to topic    KWSN Orbiting Fortress Forum Index -> DC News
View previous topic :: View next topic  
Author Message
branjo
Prince
Prince


Joined: 05 Jan 2006
Posts: 746
Location: Slovakia

PostPosted: Fri Nov 08, 2013 2:05 pm    Post subject: New WCG project launched - Mapping Cancer Markers Reply with quote

Quote:
Most cancers lack effective markers to detect disease early, to identify high risk patients (prognostic signatures), and to predict optimal treatment strategy (predictive signatures). The main challenge is learning from and using the enormous amounts of complex, molecular data from tumor samples. Many methods have been introduced to generate prognostic and predictive signatures from these data, but we lack systematic approaches to find all useful signatures, and to select the best one.

Counter intuitively, good signatures comprise not only the most
differential markers. Identifying these less differential markers - "the best supporting actors" - calls for novel, integrative approaches as current statistical and machine learning methods fail in this task.

The Mapping Cancer Markers (MCM; http://www.cs.utoronto.ca/~juris/MCM.htm )
project aims to comprehensively and systematically discover clinically
useful markers to help:

1. Detect cancer early,
2. Identify high-risk patients, and
3. Predict treatment response.

To power this research, we rely on World Community Grid volunteers who
donate their computers' spare capacity to carry out this extensive
analysis. Finding all clinically useful markers would require processing thousands of patient samples and testing an astronomical number of marker combinations, which is not feasible even on World Community Grid.

We developed approaches called heuristics to reduce the search space,
enabling us to tackle this challenge. However, the success of MCM project is only enabled by World Community Grid with the computing resources donated by volunteers around the world.

Considering the diversity of analyses and data, we will have large
variation in runtimes and work unit duration. We will keep you updated on the progress and discoveries, and would be happy to answer any questions you may have about the project.

We hope you will find our project interesting, and support its goals. With your participation, we will form the largest "cancer research team" in the world


http://www.worldcommunitygrid.org/research/mcm1/overview.do

http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,35773

Badges:
Bronze
Silver
Gold
Ruby
Emerald
Sapphire

#ni-1

ETA: new design observations and help (some features changed their placements Sad )

http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,35774
http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,35778
_________________



Back to top
View user's profile Send private message Visit poster's website
LanDroid
Prince
Prince


Joined: 11 Jun 2002
Posts: 4386
Location: Cincinnati, OH U.S.

PostPosted: Sat Nov 09, 2013 5:38 pm    Post subject: Reply with quote

Can anyone beat branjo to the bronze?

#ni-2
_________________

Back to top
View user's profile Send private message Visit poster's website AIM Address
branjo
Prince
Prince


Joined: 05 Jan 2006
Posts: 746
Location: Slovakia

PostPosted: Sun Nov 10, 2013 2:11 pm    Post subject: Reply with quote

I am sure at least Sir Yankton will earn badges sooner than me - my 12 threads are not that threat #ni-1
_________________



Back to top
View user's profile Send private message Visit poster's website
Yankton
Prince
Prince


Joined: 27 Sep 2008
Posts: 1697
Location: California

PostPosted: Sun Nov 10, 2013 4:48 pm    Post subject: Reply with quote

I'm not doing overly much WCG. Focused on primegrid and seti. I've only been pulling WCG when they refuse to pull cpu units for PG and seti.

go for it!
_________________
Some days are worse than others.
Back to top
View user's profile Send private message
branjo
Prince
Prince


Joined: 05 Jan 2006
Posts: 746
Location: Slovakia

PostPosted: Thu Nov 14, 2013 9:05 am    Post subject: Reply with quote

Temporary pause for the Mapping Cancer Markers project

Quote:
We launched the Mapping Cancer Markers project this week and accelerated the first batch so that we could check the results sooner for any anomalies. Unfortunately, we found a limitation with the default random number generator being used for the project. The increased volume of results revealed some duplication of computation due to this. That is, the results computed are valid and correct, but in some cases they are duplicated instead of exploring new regions of the search space. For this reason, we are temporarily pausing the project and making some code changes to improve the random number generator usage. We will run a brief beta test for this change and if all looks good, will soon (in a few days) resume the project at full speed. The nature of research is that it often contains unexpected surprises and this is just one of them. Members will receive the normal credits for the work already performed. Thank you for your contributions and support of the project and more importantly thank you for your patience with this.


Rolling Eyes
_________________



Back to top
View user's profile Send private message Visit poster's website
Plomos
Prince
Prince


Joined: 26 Apr 2011
Posts: 852

PostPosted: Thu Nov 14, 2013 11:20 am    Post subject: Reply with quote

Just means more time for PG as they work stuff out, then race to the bronze
_________________

Back to top
View user's profile Send private message
LanDroid
Prince
Prince


Joined: 11 Jun 2002
Posts: 4386
Location: Cincinnati, OH U.S.

PostPosted: Fri Nov 15, 2013 12:43 pm    Post subject: Reply with quote

Race for the bronze? branjo already has the silver!
_________________

Back to top
View user's profile Send private message Visit poster's website AIM Address
branjo
Prince
Prince


Joined: 05 Jan 2006
Posts: 746
Location: Slovakia

PostPosted: Fri Nov 15, 2013 2:50 pm    Post subject: Reply with quote

I like my grey hair Cool

But two top WCG kaNI!ghts have already achieved Sapphire and [s]Ruby[/s] Emerald

#ni-2
_________________



Back to top
View user's profile Send private message Visit poster's website
Gustine
Guest





PostPosted: Sat Nov 30, 2013 4:07 am    Post subject: Reply with quote

Although not really understand, but I support.
Back to top
LanDroid
Prince
Prince


Joined: 11 Jun 2002
Posts: 4386
Location: Cincinnati, OH U.S.

PostPosted: Sun Dec 01, 2013 12:18 am    Post subject: Reply with quote

That is better than "I'm against it - what is it?" Laughing
_________________

Back to top
View user's profile Send private message Visit poster's website AIM Address
Yankton
Prince
Prince


Joined: 27 Sep 2008
Posts: 1697
Location: California

PostPosted: Sun Dec 01, 2013 1:38 am    Post subject: Reply with quote

https://www.youtube.com/watch?v=ERTT_sv8sV0

#ni-1
_________________
Some days are worse than others.
Back to top
View user's profile Send private message
Sir Cracked of the Mind
Prince
Prince


Joined: 03 Feb 2004
Posts: 1681
Location: Ramsgate

PostPosted: Sat Mar 18, 2017 8:43 am    Post subject: Reply with quote

Yankton the link is dead, they closed the account down.... #ni-1
_________________
我們是誰說鎳的騎士!



Back to top
View user's profile Send private message
Display posts from previous:   
Post new topic   Reply to topic    KWSN Orbiting Fortress Forum Index -> DC News All times are GMT - 5 Hours
Page 1 of 1

 
Jump to:  
You cannot post new topics in this forum
You cannot reply to topics in this forum
You cannot edit your posts in this forum
You cannot delete your posts in this forum
You cannot vote in polls in this forum


Powered by phpBB © 2001, 2005 phpBB Group
Optimized Seti@Home App | BOINC Stats